Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4

@inproceedings{Paracuellos2015InsightsIC,
  title={Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4},
  author={Patricia Paracuellos and David C. Briggs and Federico Carafoli and Tan Lon{\vc}ar and Erhard Hohenester},
  booktitle={Structure},
  year={2015}
}
The C-type mannose receptor and its homolog Endo180 (or uPARAP, for urokinase plasminogen activator receptor-associated protein) mediate the endocytic uptake of collagen by macrophages and fibroblasts. This process is required for normal tissue remodeling, but also facilitates the growth and dissemination of tumors. We have determined the crystal structure at 2.5 Å resolution of the N-terminal region of Endo180, consisting of a ricin-like domain, a fibronectin type II (FN2) domain, and two C… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 18 times over the past 90 days. VIEW TWEETS
2 Citations
61 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…