Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.

  title={Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.},
  author={Timothy P Stinear and Torsten Seemann and Paul F Harrison and Grant A. Jenkin and John K. Davies and Paul D R Johnson and Z. Nait Abdellah and Claire Arrowsmith and Tracey Chillingworth and Carol M Churcher and Kay Clarke and Ann Cronin and Paul Davis and I Goodhead and Nancy Holroyd and Kay Jagels and Angela Lord and Sharon Moule and Karen Mungall and Halina T Norbertczak and Michael A. Quail and Ester Rabbinowitsch and Danielle L Walker and Brian White and Sally Whitehead and Pamela Long Claus Small and Roland Brosch and L. Ramakrishnan and Michael A. Fischbach and Julian 5 Parkhill and Stewart T Cole},
  journal={Genome research},
  volume={18 5},
Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid. Prominent features are the very large number of genes (57) encoding polyketide synthases (PKSs) and nonribosomal peptide synthases (NRPSs) and the most extensive repertoire yet… CONTINUE READING
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