Insights from the architecture of the bacterial transcription apparatus.

@article{Iyer2012InsightsFT,
  title={Insights from the architecture of the bacterial transcription apparatus.},
  author={Lakshminarayan M. Iyer and L. Aravind},
  journal={Journal of structural biology},
  year={2012},
  volume={179 3},
  pages={299-319}
}
We provide a portrait of the bacterial transcription apparatus in light of the data emerging from structural studies, sequence analysis and comparative genomics to bring out important but underappreciated features. We first describe the key structural highlights and evolutionary implications emerging from comparison of the cellular RNA polymerase subunits with the RNA-dependent RNA polymerase involved in RNAi in eukaryotes and their homologs from newly identified bacterial selfish elements. We… CONTINUE READING
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