Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome

@article{Komaroff2021InsightsFM,
  title={Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome},
  author={Anthony L. Komaroff and W. Ian Lipkin},
  journal={Trends in Molecular Medicine},
  year={2021},
  volume={27},
  pages={895 - 906}
}

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

TLDR
The evidence is summarized that people with acute COVID-19 and with ME/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.

TLDR
Most PASC patients evaluated at the authors' clinic had no comorbid condition and were not hospitalized for acute COVID-19, but one-third of patients experienced a severe decline in their functional status.

The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure

TLDR
From this review, it is concluded that the multifaceted pathobiology of ME/CFS may be attributable in a unifying manner to neuroglial dysfunction.

Unexplained post-acute infection syndromes.

TLDR
What is known about unexplained PAISs is summarized, context for post-acute sequelae of SARS-CoV-2 infection (PASC), and the need for basic biomedical research into the underlying mechanisms behind this group of enigmatic chronic illnesses are delineated.

Molecular Mechanisms of Neuroinflammation in ME/CFS and Long COVID to Sustain Disease and Promote Relapses

TLDR
The hypothesis is proposed that following the initial stressor event, the subsequent systemic pathology moves to the brain via neurovascular pathways or through a dysfunctional blood-brain barrier (BBB), resulting in chronic neuroinflammation and leading to a sustained illness with chronic relapse recovery cycles.

Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

TLDR
This paper summarizes and expands on the previous publications about the relevance of findings from critical illness for ME/CFS and describes interlinkages between these pathophysiological mechanisms as well as “vicious cycles” involving cytokines and inflammation that may contribute to explain the chronic nature of these illnesses.

Post-acute COVID-19 syndrome.

TLDR
A comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae is provided and a framework for the identification of those at high risk for post-ACute CO VID-19 and their coordinated management through dedicated COVID -19 clinics is proposed.

Neurocognitive and psychiatric post-coronavirus disease 2019 conditions: pathogenic insights of brain dysfunction following severe acute respiratory syndrome coronavirus 2 infection

TLDR
Neurocognitive and psychiatric post-COVID-19 long-term conditions are frequent and complex multifactorial sequelae that include microglial activation and astrogliosis.

Orthostatic Challenge Causes Distinctive Symptomatic, Hemodynamic and Cognitive Responses in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

TLDR
An Orthostatic challenge easily performed in an office setting, and the use of a smart phone app to assess cognition, can provide objective confirmation of the orthostatic intolerance and brain fog reported by patients with Long COVID and ME/CFS.

Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

TLDR
There is a strong case for this area of research to be revived and clinicians would be justified in offering a course of IgG to selected ME/CFS patients at the more severe end of the spectrum, and it is suggested that IgG treatment may be pertinent to the care of some patients who remain ill following infection with SARS-CoV-2 virus.

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Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

TLDR
The evidence is summarized that people with acute COVID-19 and with ME/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state.

Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

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