Insights from investigating the interactions of adamantane-based drugs with the M2 proton channel from the H1N1 swine virus.

@article{Wang2009InsightsFI,
  title={Insights from investigating the interactions of adamantane-based drugs with the M2 proton channel from the H1N1 swine virus.},
  author={Jing-Fang Wang and Dongqing Wei and Kuo-Chen Chou},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={388 2},
  pages={
          413-7
        }
}
The M2 proton channel is one of indispensable components for the influenza A virus that plays a vital role in its life cycle and hence is an important target for drug design against the virus. In view of this, the three-dimensional structure of the H1N1-M2 channel was developed based on the primary sequence taken from a patient recently infected by the H1N1 (swine flu) virus. With an explicit water-membrane environment, molecular docking studies were performed for amantadine and rimantadine… Expand
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