Insights from animal models on the origins and progression of retinoblastoma.

  title={Insights from animal models on the origins and progression of retinoblastoma.},
  author={Marek Pacal and Rod Bremner},
  journal={Current molecular medicine},
  volume={6 7},
The RB gene was discovered 20 years ago because of its role in the childhood eye cancer retinoblastoma. However, surprisingly little progress was made in defining the role of RB protein in the retina. In the last two years, new models exploiting conditional deletion of the mouse Rb gene have altered this picture radically. These models provide insight into the first Rb function, the cell of origin of retinoblastoma, the window during which Rb acts, distinct cell-specific defenses against Rb… CONTINUE READING

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