Insights derived from ACE knockout mice.

  title={Insights derived from ACE knockout mice.},
  author={Justin M Cole and Dilek Ertoy and K. E. Bernstein},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  volume={1 2},
The evaluation of ACE knockout mice has illustrated the tremendous physiologic importance of the RAAS. We have discussed how interruption of this system influences blood pressure, renal function, renal development, serum and urine electrolyte composition, haematocrit and male reproductive capacity. This body of data underlines the modelling of the RAAS as a type of biological machine that is positioned to respond to environmental insult and to maintain a homeostasis of blood pressure, blood… CONTINUE READING

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