Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia.
Approximately one-third of the total deaths worldwide per annum, amounting to 16.6 million people, is due to cardiovascular disease , making it the number one cause of death . Cardiovascular disease also has a major impact on morbidity . Thus, reducing the incidence of deaths due to vascular disease/complications and developing better treatment strategies, remains a central goal for national economies worldwide [3, 4]. Consequently, several animal models have been developed to replicate human vascular diseases, in order to study the pathophysiology of disease progression and novel therapeutic options. This issue of The Open Cardiovascular Medicine Journal discusses some of these models. In this Editorial, each review article for the Special Issue will be briefly outlined, with consideration given to a few additional models.