Insights Into Protein S-Palmitoylation in Synaptic Plasticity and Neurological Disorders: Potential and Limitations of Methods for Detection and Analysis

@inproceedings{ZarbaKozio2018InsightsIP,
  title={Insights Into Protein S-Palmitoylation in Synaptic Plasticity and Neurological Disorders: Potential and Limitations of Methods for Detection and Analysis},
  author={Monika Zaręba-Kozioł and Izabela Figiel and Anna Bartkowiak-Kaczmarek and Jakub Włodarczyk},
  booktitle={Front. Mol. Neurosci.},
  year={2018}
}
S-palmitoylation (S-PALM) is a lipid modification that involves the linkage of a fatty acid chain to cysteine residues of the substrate protein. This common posttranslational modification (PTM) is unique among other lipid modifications because of its reversibility. Hence, like phosphorylation or ubiquitination, it can act as a switch that modulates various important physiological pathways within the cell. Numerous studies revealed that S-PALM plays a crucial role in protein trafficking and… CONTINUE READING