Insight onto the pathophysiology and clinical complications of thalassemia intermedia.

@article{Cappellini2009InsightOT,
  title={Insight onto the pathophysiology and clinical complications of thalassemia intermedia.},
  author={Maria Domenica Cappellini and Khaled M. Musallam and Ali T Taher},
  journal={Hemoglobin},
  year={2009},
  volume={33 Suppl 1},
  pages={S145-59}
}
Our understanding of the molecular and pathophysiological mechanisms underlying the disease process in patients with thalassemia intermedia (TI) has substantially increased over the past decade. TI encompasses a wide clinical spectrum of beta-thalassemia phenotypes. Some TI patients are asymptomatic until adult life, whereas others are symptomatic from as young as 2 years. A number of clinical complications commonly associated with TI are rarely seen in thalassemia major, including… CONTINUE READING