Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel.

@article{Li2014InsightIT,
  title={Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel.},
  author={Qingxin Li and Hui Qi Amanda Ng and Ho sup Yoon and Congbao Kang},
  journal={FEBS letters},
  year={2014},
  volume={588 17},
  pages={
          2782-8
        }
}
The gating of the hERG channel is regulated by its eag domain through molecular interaction with either the cyclic nucleotide-binding homology domain (CNBHD) or the linker between transmembrane segments 4 and 5. Our NMR study on the purified CNBHD demonstrated that it contains nine β-strands and does not bind cAMP. We show that the eag domain binds to the CBND through an interface containing several disease-associated mutations. The N-terminal cap domain and R56 in the eag domain are important… CONTINUE READING
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