Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.

  title={Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.},
  author={Veronique Dani{\"e}ls and Ren{\'e}e Vancraenenbroeck and Bernard M.H. Law and Elisa Greggio and Evy Lobbestael and Fangye Gao and Marc de Maeyer and Mark R Cookson and Kirsten Harvey and Veerle Baekelandt and Jean-Marc Taymans},
  journal={Journal of neurochemistry},
  volume={116 2},
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent known cause of autosomal dominant Parkinson's disease. The LRRK2 gene encodes a Roco protein featuring a Ras of complex proteins (ROC) GTPase and a kinase domain linked by the C-terminal of ROC (COR) domain. Here, we explored the effects of the Y1699C pathogenic LRRK2 mutation in the COR domain on GTPase activity and interactions within the catalytic core of LRRK2. We observed a decrease in GTPase activity for… CONTINUE READING


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