Insight into the Effect of Inhibitor Resistant S130G Mutant on Physico-Chemical Properties of SHV Type Beta-Lactamase: A Molecular Dynamics Study

@article{Baig2014InsightIT,
  title={Insight into the Effect of Inhibitor Resistant S130G Mutant on Physico-Chemical Properties of SHV Type Beta-Lactamase: A Molecular Dynamics Study},
  author={Mohd Hassan Baig and D. Raja Sudhakar and Ponnusamy Kalaiarasan and Naidu Subbarao and Gulshan Wadhawa and Mohtashim Lohani and M. Kalim A. Khan and Asad U. Khan},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Bacterial resistance is a serious threat to human health. The production of β-lactamase, which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics. The Class A enzymes are most frequently encountered among the four β-lactamases in the clinic isolates. Mutations in class A β-lactamases play a crucial role in substrate and inhibitor specificity. SHV and TEM type are known to be most common class A β-lactamases. In the present study, we have analyzed the effect of… 
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