Insight into the Chemical Mechanism of Thymidylate Synthase-Catalyzed Reaction Through the Evaluation of Chemical Models: The Role of C6 Sulfhydryl Addition During the Reductive Elimination Step of the Reaction1

@inproceedings{Wang1994InsightIT,
  title={Insight into the Chemical Mechanism of Thymidylate Synthase-Catalyzed Reaction Through the Evaluation of Chemical Models: The Role of C6 Sulfhydryl Addition During the Reductive Elimination Step of the Reaction1},
  author={Binghe Wang and John R. Kagel and Mathias P. Mertes and Kristin Bowman-James},
  year={1994}
}
Abstract Thymidylate synthase catalyzes the last step of the de novo synthesis of thymidine-5′-monophosphate (TMP), which has long been a target for the development of effective anticancer agents. Model compounds (15, 16, 17) were used to study the effect of C6 nucleophilic addition on the reductive elimination step of the TS-catalyzed reaction. Results suggest that C6 addition facilitates the reductive elimination of the H 2 folate moiety of the ternary intermediate (3). Therefore, the… CONTINUE READING

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