Insight into oxidative stress in varicocele-associated male infertility: part 2

  title={Insight into oxidative stress in varicocele-associated male infertility: part 2},
  author={Alaa Hamada and Sandro C. Esteves and Ashok Agarwal},
  journal={Nature Reviews Urology},
Varicocele, the leading cause of male infertility, can impair spermatogenesis through several pathophysiological mechanisms. Of these, current evidence suggests that oxidative stress is the central element contributing to infertility in men with varicocele, to which the testis responds by way of heat stress, ischaemia or production of vasodilators, such as nitric oxide. Surgical varicocele repair (varicocelectomy) is beneficial not only for alleviating oxidative stress-associated infertility… CONTINUE READING


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