Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.

@article{Kheifets2007InsightII,
  title={Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.},
  author={Viktoria Kheifets and Daria Mochly-Rosen},
  journal={Pharmacological research},
  year={2007},
  volume={55 6},
  pages={467-76}
}
Protein kinase C (PKC) is a family of kinases that are critical in many cellular events. These enzymes are activated by lipid-derived second messengers, are dependent on binding to negatively charged phospholipids and some members also require calcium to attain full activation. The interaction with lipids and calcium activators is mediated by binding to the regulatory domains C1 and C2. In addition, many protein-protein interactions between PKC and other proteins have been described. These… CONTINUE READING

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