Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.

Abstract

Whole-exome sequencing has been incredibly successful in identifying causal genetic variants and has revealed a number of novel genes associated with blood and other diseases. One limitation of this approach is that it overlooks mutations in noncoding regulatory elements. Furthermore, the mechanisms by which mutations in transcriptionalcis-regulatory… (More)
DOI: 10.1073/pnas.1521754113

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Cite this paper

@article{Wakabayashi2016InsightIG, title={Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.}, author={Aoi Wakabayashi and Jacob C. Ulirsch and Leif Si-Hun Ludwig and Claudia Fiorini and Makiko Yasuda and Avik Choudhuri and Patrick E McDonel and Leonard I. Zon and Vijay G Sankaran}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2016}, volume={113 16}, pages={4434-9} }