Insight into Crohn’s disease pathomorphology

  title={Insight into Crohn’s disease pathomorphology},
  author={Jonas Mudter and Markus F Neurath},
  journal={Abdominal Imaging},
Crohn’s disease (CD) belongs together with ulcerative colitis to the two major forms of inflammatory bowel diseases (IBD). Although its etiology remains poorly understood, several genetic and immune factors and cells (especially T cells) have been shown to be involved in the pathogenesis of IBD. Among these factors, proinflammatory T cells and their secreted cytokines seem to be the main effectors in induction and perpetuation of the intestinal inflammation. Beside the local inflammatory effect… CONTINUE READING


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