Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

@article{Sun2005InsigRF,
  title={Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.},
  author={Li-Ping Sun and Lu Li and Joseph L Goldstein and Michael Sean Brown},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 28},
  pages={
          26483-90
        }
}
When added to living cells, sterols such as cholesterol and 25-hydroxycholesterol block the lateral movement of sterol regulatory element-binding proteins (SREBPs) into COPII-coated vesicles on endoplasmic reticulum (ER) membranes and thereby prevent the SREBPs from reaching the Golgi complex for processing to the mature forms that activate cholesterol synthesis. Sorting of SREBPs into COPII vesicles is mediated by Sar1 and the coat proteins Sec23 and Sec24. Here, we explore the mechanism of… CONTINUE READING

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Regulated Sorting of Scap/SREBP into COPII Vesicles

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