Inside-out red cell membrane vesicles: preparation and purification.


Plasma membranes purified from human red cells were Converted into small vesicleS by disruption in alkaline buffer of low ionic strength. Most of these vesicles were inside-out. The presence of divalent cations prevented this inversion. The inside-out vesicles were separatcd from right-side-out vesicles by centrifugration to equilibrium in dextran density gradients.

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@article{Steck1970InsideoutRC, title={Inside-out red cell membrane vesicles: preparation and purification.}, author={T L Steck and Ronald S. Weinstein and June Hookey Straus and David Wallach}, journal={Science}, year={1970}, volume={168 3928}, pages={255-7} }