Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization.

@article{Hartmann2015InsideoutRO,
  title={Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization.},
  author={Monika Hartmann and L. M. Martı́n Parra and Anne Ruschel and Christina Lindner and Helen L. Morrison and Andreas Herrlich and Peter A. Herrlich},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 28},
  pages={17041-54}
}
Ectodomain shedding of transmembrane precursor proteins generates numerous life-essential molecules, such as epidermal growth factor receptor ligands. This cleavage not only releases the regulatory growth factor, but it is also the required first step for the subsequent processing by γ-secretase and the release of gene regulatory intracellular fragments… CONTINUE READING