Inside-out Ca2+ signalling prompted by STIM1 conformational switch

  title={Inside-out Ca2+ signalling prompted by STIM1 conformational switch},
  author={Guolin Ma and Ming Yue Wei and Lian He and Chongxu Liu and Bo Wu and Shenyuan L. Zhang and Ji Jing and Xiaowen Liang and Alessandro Senes and Peng Tan and Siwei Li and Aomin Sun and Yunchen Bi and Ling Zhong and Hongjiang Si and Yuequan Shen and Minyong Li and Mi-Sun Lee and Weibin Zhou and Junfeng Wang and Youjun Wang and Yubin Zhou},
  booktitle={Nature communications},
Store-operated Ca(2+) entry mediated by STIM1 and ORAI1 constitutes one of the major Ca(2+) entry routes in mammalian cells. The molecular choreography of STIM1-ORAI1 coupling is initiated by endoplasmic reticulum (ER) Ca(2+) store depletion with subsequent oligomerization of the STIM1 ER-luminal domain, followed by its redistribution towards the plasma membrane to gate ORAI1 channels. The mechanistic underpinnings of this inside-out Ca(2+) signalling were largely undefined. By taking advantage… CONTINUE READING
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Initial activation of STIM 1 , the regulator of storeoperated calcium entry

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