Inside out: the role of nucleocytoplasmic transport in ALS and FTLD

  title={Inside out: the role of nucleocytoplasmic transport in ALS and FTLD},
  author={Steven Boeynaems and E. Titeca-van Bogaert and Philip Van Damme and Ludo Van Den Bosch},
  booktitle={Acta Neuropathologica},
Neurodegenerative diseases are characterized by the presence of protein inclusions with a different protein content depending on the type of disease. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are no exceptions to this common theme. In most ALS and FTLD cases, the predominant pathological species are RNA-binding proteins. Interestingly, these proteins are both depleted from their normal nuclear localization and aggregated in the cytoplasm. This key… CONTINUE READING
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