Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination

@article{Tsunoda2002InsideOutVO,
  title={Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination},
  author={Ikuo Tsunoda and Robert Shin Fujinami},
  journal={Springer Seminars in Immunopathology},
  year={2002},
  volume={24},
  pages={105-125}
}
The primary target in multiple sclerosis (MS) is believed to be either myelin itself (myelinopathy) or the myelin-forming cell, the oligodendrocyte (oligodendrogliopathy). Although axonal injury occurs in MS, it is regarded as a secondary event to the myelin damage. Here, the lesion develops from myelin (outside) to the axon (inside) (Outside-In model… CONTINUE READING