Inside Out: Core Network of Transcription Factors Drives Axon Regeneration

Abstract

In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.

DOI: 10.1016/j.neuron.2016.02.022

Cite this paper

@article{Yoon2016InsideOC, title={Inside Out: Core Network of Transcription Factors Drives Axon Regeneration}, author={Choya Yoon and Roman J Giger}, journal={Neuron}, year={2016}, volume={89}, pages={881-884} }