Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat.

@article{Katayama2011InsertionalMI,
  title={Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat.},
  author={Kentaro Katayama and Tetsu Sasaki and Syo Goto and Kei Ogasawara and Hiromi Maru and Katsushi Suzuki and Hiroetsu Suzuki},
  journal={Bone},
  year={2011},
  volume={49 5},
  pages={1027-36}
}
Homozygous rats (ocd/ocd) of a mutant inbred strain, OCD (osteochondrodysplasia), show osteochondrodysplasia, systemic edema, cleft palate, protruding tongue, disproportionate dwarfism, and lethality immediately after birth. Their epiphyses show decreased levels of glycosaminoglycans and weak staining for extracellular matrix proteins. The epiphyseal chondrocytes have large vesicles and expanded endoplasmic reticulum and Golgi apparatus. These phenotypic features are inherited in an autosomal… CONTINUE READING
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