Corpus ID: 44904367

Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.

@article{BenDavid1990InsertionalIO,
  title={Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes.},
  author={Y. Ben-David and A. Lavigueur and G. Cheong and A. Bernstein},
  journal={The New biologist},
  year={1990},
  volume={2 11},
  pages={
          1015-23
        }
}
Rearrangements within the p53 gene are observed in a high proportion of independent erythroleukemic cell lines derived from the spleens of mice infected with Friend leukemia virus. The majority of cells with at least one rearranged p53 allele do not express detectable levels of p53 protein. Here, we show that in 4 out of 19 newly established erythroleukemic cell lines induced by infecting DBA mice with either the anemia (FV-A) or polycythemia (FV-P)-inducing strains of Friend virus, the p53… Expand
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