Insertion of the tetracycline resistance translocation unit Tn10 in thelac operon ofEscherichia coli K12

@article{Foster1977InsertionOT,
  title={Insertion of the tetracycline resistance translocation unit Tn10 in thelac operon ofEscherichia coli K12},
  author={T. J. Foster},
  journal={Molecular and General Genetics MGG},
  year={1977},
  volume={154},
  pages={305-309}
}
The majority of Tn10 insertions in thelacZ gene ofEscherichia coli occurred in a small region of the promoter distal part of the gene. The resulting mutations were polar onlacY and reverted to Lac+ at a frequency of 10-8. None of the revertants were Tc4. Furthermore Lac+ Tcr revertants could not be selected directly. Relief of polarity revertants of thelacZ::Tn10 mutants were formed at a frequency of 10-5–10-4. Most resulted from a deletion event internal to the transposon which removed the Tcr… CONTINUE READING

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