Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.

  title={Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.},
  author={A. Gabrea and P. L. Bergsagel and M. Chesi and Y. Shou and W. Kuehl},
  journal={Molecular cell},
  volume={3 1},
  • A. Gabrea, P. L. Bergsagel, +2 authors W. Kuehl
  • Published 1999
  • Medicine, Biology
  • Molecular cell
  • Oncogenes are often dysregulated in B cell tumors as a result of a reciprocal translocation involving an immunoglobulin locus. The translocations are caused by errors in two developmentally regulated DNA recombination processes: V(D)J and IgH switch recombination. Both processes share the property of joining discontinuous sequences from one chromosome and releasing intervening sequences as circles that are lost from progeny cells. Here we show that these intervening sequences may instead insert… CONTINUE READING
    Mechanisms of chromosomal translocations in B cell lymphomas
    • 573
    • Open Access
    The Pathogenetic Role of Oncogenes Deregulated by Chromosomal Translocation in B-Cell Malignancies
    • 23
    Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma.
    • 51
    • Open Access
    Chromosome translocations in multiple myeloma
    • 416
    • Open Access
    The enigmatic role of cyclin D1 in multiple myeloma
    • 31
    • Open Access


    Publications referenced by this paper.
    DNA Transposition by the RAG1 and RAG2 Proteins A Possible Source of Oncogenic Translocations
    • 520
    • Open Access
    Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes.
    • 271
    Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • 722
    V(D)J recombinase activity in a subset of germinal center B lymphocytes.
    • 305
    V(D)J recombination in mature B cells: a mechanism for altering antibody responses.
    • 246