Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.

@article{Gabrea1999InsertionOE,
  title={Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell.},
  author={Ana Gabrea and Peter Leif Bergsagel and Marta Chesi and Yaping Shou and Walter Michael Kuehl},
  journal={Molecular cell},
  year={1999},
  volume={3 1},
  pages={119-23}
}
Oncogenes are often dysregulated in B cell tumors as a result of a reciprocal translocation involving an immunoglobulin locus. The translocations are caused by errors in two developmentally regulated DNA recombination processes: V(D)J and IgH switch recombination. Both processes share the property of joining discontinuous sequences from one chromosome and releasing intervening sequences as circles that are lost from progeny cells. Here we show that these intervening sequences may instead insert… CONTINUE READING