Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription.

@article{Yu2004InsertionOA,
  title={Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription.},
  author={Ling Yu and Katsuyuki Hamada and Masayoshi Namba and Kenji Kadomatsu and Takashi Muramatsu and Shuichiro Matsubara and Masatoshi Tagawa},
  journal={Cancer letters},
  year={2004},
  volume={203 1},
  pages={51-7}
}
Insertion of an exogenous promoter into adenoviral regulatory regions may result in altered specificity and activity of the integrated promoter-mediated transcription in the context of recombinant adenoviruses (Ad). The alteration is due to the influence of the viral regulatory elements. Specificity of oncolytic Ad, in which the E1A expression is designed to be controlled by a tumor-specific promoter, could thus be modulated by the Ad E1A enhancer/promoters. We prepared recombinant Ad bearing a… CONTINUE READING

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