Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.

@article{EconomouPachnis1985InsertionOA,
  title={Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.},
  author={A Economou-Pachnis and Philip N Tsichlis},
  journal={Nucleic acids research},
  year={1985},
  volume={13 23},
  pages={8379-87}
}
Fifty-nine human DNA samples derived from either normal tissues or hematopoietic neoplasias were examined for rearrangements in the Mlvi-2 locus, a putative oncogene. The rearranged Mlvi-2 sequences in one of them, a B cell lymphoma, were shown to result from the insertion of an approximately 300 bp DNA fragment that hybridized to a human Alu probe. DNA sequence analysis of both the rearranged and the nonrearranged allele around the site of the insertion revealed the following: a) the insert… CONTINUE READING