Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice.

@article{Zhao2004InsertionOA,
  title={Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice.},
  author={Haotian Zhao and Ying Yang and Christian M Rizo and Paul Overbeek and M. L. Robinson},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 6},
  pages={1930-9}
}
PURPOSE Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene expression to the entire lens but not to the corneal epithelium. METHODS Transgenic mice were generated with fragments of the murine alphaA- and alphaB-crystallin promoters, as… CONTINUE READING
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