Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

@article{Brown2000InsertionOI,
  title={Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions},
  author={Chester W Brown and Dianne E. Houston-Hawkins and Teresa K. Woodruff and Martin M. Matzuk},
  journal={Nature Genetics},
  year={2000},
  volume={25},
  pages={453-457}
}
The activins (dimers of βA or βB subunits, encoded by the genes Inhba and Inhbb, respectively) are TGF-β superfamily members that have roles in reproduction and development1,2,3. Whereas mice homozygous for the Inhba-null allele demonstrate disruption of whisker, palate and tooth development, leading to neonatal lethality4,5, homozygous Inhbb-null mice are viable, fertile and have eye defects6,7. To determine if these phenotypes were due to spatiotemporal expression differences of the ligands… CONTINUE READING
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Activins, inhibins, and follistatins: further thoughts on a growing family of regulators.

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