Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.

Abstract

The envelope (E) protein of Dengue virus rearranges to a trimeric hairpin to mediate fusion of the viral and target membranes, which is essential for infectivity. Insertion of E into the target membrane serves to anchor E and possibly also to disrupt local order within the membrane. Both aspects are likely to be affected by the depth of insertion… (More)
DOI: 10.1016/j.bbamem.2018.02.012

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