Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.

  title={Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.},
  author={Samra Turajlic and Kevin Litchfield and Hang Xu and Rachel Rosenthal and Nicholas McGranahan and James L. Reading and Yien Ning Sophia Wong and Andrew Rowan and Nnennaya Kanu and Maise Al Bakir and Tim Chambers and Roberto Salgado and Peter Savas and Sherene Loi and Nicolai J. Birkbak and Laurent Sansregret and Martin Eric Gore and James M. G. Larkin and Sergio A Quezada and Charles Swanton},
  journal={The Lancet. Oncology},
  volume={18 8},
BACKGROUND The focus of tumour-specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of small insertions and deletions (indels) less well characterised. We investigated whether the frameshift nature of indel mutations, which create novel open reading frames and a large quantity of mutagenic peptides highly distinct from self, might contribute to the immunogenic phenotype. METHODS We analysed whole-exome sequencing data from 5777 solid tumours, spanning… CONTINUE READING


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