Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System

@article{MllerHergt2018InsertionDO,
  title={Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System},
  author={Braulio Vargas M{\"o}ller-Hergt and Andreas Carlstr{\"o}m and T. Suhm and M. Ott},
  journal={Cells},
  year={2018},
  volume={7}
}
  • Braulio Vargas Möller-Hergt, Andreas Carlström, +1 author M. Ott
  • Published 2018
  • Chemistry, Medicine
  • Cells
  • The mitochondrial proteome contains proteins from two different genetic systems. Proteins are either synthesized in the cytosol and imported into the different compartments of the organelle or directly produced in the mitochondrial matrix. To ensure proteostasis, proteins are monitored by the mitochondrial quality control system, which will degrade non-native polypeptides. Defective mitochondrial membrane proteins are degraded by membrane-bound AAA-proteases. These proteases are regulated by… CONTINUE READING
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