Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and loss of the insertion allele in aldosterone-producing adenoma.

@article{Tunny1996InsertiondeletionPO,
  title={Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and loss of the insertion allele in aldosterone-producing adenoma.},
  author={Terry J. Tunny and Li Xu and Kim A. Richardson and Michael Stowasser and Michael G. Gartside and Richard Gordon},
  journal={Journal of human hypertension},
  year={1996},
  volume={10 12},
  pages={827-30}
}
The genetic mechanisms responsible for the formation of adrenocortical adenomas which autonomously produce aldosterone are largely unknown. The adrenal renin-angiotensin system has been implicated in the pathophysiology of these tumours. Angiotensin-converting enzyme (ACE) catalyses the generation of angiotensin II, and the insertion/deletion (I/D) polymorphism of the ACE gene regulates up to 50% of plasma and cellular ACE variability in humans. We therefore examined the genotypic and allelic… CONTINUE READING