Insensitivity to future consequences following damage to human prefrontal cortex

  title={Insensitivity to future consequences following damage to human prefrontal cortex},
  author={Antoine Bechara and Antonio R. Damasio and Hanna Damasio and Steven W. Anderson},

Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.

A physiological correlate for the defect of prefrontal damage is identified and its possible significance is discussed, compatible with the idea that these patients fail to activate biasing signals that would serve as value markers in the distinction between choices with good or bad future outcomes.

Orbitofrontal cortex and its contribution to decision-making.

  • J. Wallis
  • Psychology, Biology
    Annual review of neuroscience
  • 2007
It is suggested that OFC plays a key role in processing reward: It integrates multiple sources of information regarding the reward outcome to derive a value signal that can be held in working memory and used by lateral and medial prefrontal cortex to plan and organize behavior toward obtaining the outcome.

Neuropsychological Approaches to Reasoning and Decision-Making

How do people reason and decide? Patients with damage to the ventromedial frontal cortex help answer this question, since their lesion renders their choices in the real world irrational, i.e., not in

Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making

VmPFC damage was associated with increased betting regardless of the odds of winning, consistent with a role of vmPFC in biasing healthy individuals towards conservative options under risk, and patients with insular cortex lesions failed to adjust their bets by the odds on the Cambridge Gamble Task, confirming the necessary role of thevmPFC and insular regions in decision-making under risk.

Impaired behavior on real-world tasks following damage to the ventromedial prefrontal cortex

Support is found for the hypothesis that VMPC patients had more impaired performances on the strategy application tasks, especially on a Multiple Errands Test that required patients to execute a series of unstructured tasks in a real-world setting (shopping mall).

Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions.

Patients with VM lesions are insensitive to future consequences, positive or negative, and are primarily guided by immediate prospects, according to this study's designs of a variant of the original gambling task.

Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex.

A robust alpha-band component of event-related potentials is found that reflected the mismatch between expected outcomes and actual outcomes in the task, correlating closely with the reward-related error obtained from a reinforcement learning model of the patient's choice behavior.

Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans.

It is found that both VMF and DLF damage leads to impaired IGT performance, and the impairment of VMF subjects, but not of DLF Subjects, seems to be largely explained by an underlying reversal learning deficit.

Examining Theories of Ventromedial Prefrontal Cortex Function

These experiments suggest a special role for the VMPFC in punishment processing, especially when a change in stimulus choice is indicated, as well as examining learning from punishment versus learning from reward.



Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes

Sorting tasks, requiring the subject to respond selectively, first to one aspect of a situation and then to another, have traditionally been regarded as sensitive indicators of brain injury, but

Frontal lobes and the temporal organization of memory.

It has now been established that the frontal cortex participates in judgements of the temporal order of recent events and of their frequency of occurrence, as well as in the planning and monitoring of the execution of self-determined sequences of responses.

The Involvement of the Frontal Lobes in Cognitive Estimation

Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man

Frontal Lobe Function and Dysfunction

This work focuses on the role of the frontal lobes in memory response preparation and motor functioning in patients with frontal lobe lesions and the effects of frontal lobe damage on these functions.

The Prefrontal Cortex