Insensitivity to future consequences following damage to human prefrontal cortex

  title={Insensitivity to future consequences following damage to human prefrontal cortex},
  author={Antoine Bechara and Antonio R. Damasio and Hanna Damasio and Steven W. Anderson},
Following damage to the ventromedial prefrontal cortex, humans develop a defect in real-life decision-making, which contrasts with otherwise normal intellectual functions. Currently, there is no neuropsychological probe to detect in the laboratory, and the cognitive and neural mechanisms responsible for this defect have resisted explanation. Here, using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and… Expand

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Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.
A physiological correlate for the defect of prefrontal damage is identified and its possible significance is discussed, compatible with the idea that these patients fail to activate biasing signals that would serve as value markers in the distinction between choices with good or bad future outcomes. Expand
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  • J. Wallis
  • Psychology, Medicine
  • Annual review of neuroscience
  • 2007
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Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions.
Patients with VM lesions are insensitive to future consequences, positive or negative, and are primarily guided by immediate prospects, according to this study's designs of a variant of the original gambling task. Expand
Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex.
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Publisher Summary The aim of this chapter is to highlight insights from the field of neuropsychology into prefrontal brain functions such as reward processing and decision-making. The ventromedialExpand
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The Prefrontal Cortex