Insensitivity to future consequences following damage to human prefrontal cortex
@article{Bechara1994InsensitivityTF,
title={Insensitivity to future consequences following damage to human prefrontal cortex},
author={Antoine Bechara and Antonio R. Damasio and Hanna Damasio and Steven W. Anderson},
journal={Cognition},
year={1994},
volume={50},
pages={7-15}
}Following damage to the ventromedial prefrontal cortex, humans develop a defect in real-life decision-making, which contrasts with otherwise normal intellectual functions. Currently, there is no neuropsychological probe to detect in the laboratory, and the cognitive and neural mechanisms responsible for this defect have resisted explanation. Here, using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and… Expand
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References
SHOWING 1-10 OF 11 REFERENCES
Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage
- Psychology, Medicine
- Neuropsychologia
- 1991
The findings suggest that the base of social knowledge that E.V.R. acquired during his normal development is still intact; and that his capacity to access and process components of such knowledge is also intact, in the conditions specified in the authors' experiment. Expand
Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
- Psychology
- 1963
Sorting tasks, requiring the subject to respond selectively, first to one aspect of a situation and then to another, have traditionally been regarded as sensitive indicators of brain injury, but… Expand
Frontal lobes and the temporal organization of memory.
- Psychology, Medicine
- Human neurobiology
- 1985
It has now been established that the frontal cortex participates in judgements of the temporal order of recent events and of their frequency of occurrence, as well as in the planning and monitoring of the execution of self-determined sequences of responses. Expand
The Involvement of the Frontal Lobes in Cognitive Estimation
- Psychology, Medicine
- Cortex
- 1978
It was found that patients with frontal lesions gave significantly more bizarre answers than patients with more posterior lesions, interpreted in terms of Luria's (1966) theory of the planning functions of the frontal lobes. Expand
Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
- Medicine, Psychology
- Neuropsychologia
- 1982
Patients with unilateral frontal- or temporal-lobe excisions and 18 normal control subjects were tested on four self-ordered tasks requiring the organization of a sequence of pointing responses, finding patients with temporal-love lesions not extending posteriorly and those with more radical hippocampal excisions exhibited material-specific deficits that varied with the side of the lesion. Expand
Frontal Lobe Function and Dysfunction
- Medicine
- 1991
This work focuses on the role of the frontal lobes in memory response preparation and motor functioning in patients with frontal lobe lesions and the effects of frontal lobe damage on these functions. Expand
Descartes’ Error. Emotion, Reason and the Human Brain. New York (Grosset/Putnam) 1994.
- Psychology
- 1994
Descartes’ error: Emotion. rationality and the human brain
- 1994