Insensitivity to future consequences following damage to human prefrontal cortex

@article{Bechara1994InsensitivityTF,
  title={Insensitivity to future consequences following damage to human prefrontal cortex},
  author={A. Bechara and A. Damasio and H. Damasio and S. Anderson},
  journal={Cognition},
  year={1994},
  volume={50},
  pages={7-15}
}
  • A. Bechara, A. Damasio, +1 author S. Anderson
  • Published 1994
  • Psychology, Medicine
  • Cognition
  • Following damage to the ventromedial prefrontal cortex, humans develop a defect in real-life decision-making, which contrasts with otherwise normal intellectual functions. Currently, there is no neuropsychological probe to detect in the laboratory, and the cognitive and neural mechanisms responsible for this defect have resisted explanation. Here, using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and… CONTINUE READING
    4,966 Citations

    Topics from this paper

    Paper Mentions

    Observational Clinical Trial
    The study aims to replicate and clarify a recently observed phenomenon whereby individuals with Autism Spectrum Disorder (ASD) switch between options in a repeated task to a greater… Expand
    ConditionsAutism Spectrum Disorder (ASD)
    InterventionBehavioral, Diagnostic Test
    Interventional Clinical Trial
    In this study the investigators aim to assess whether transcranial direct current stimulation (tDCS; a safe non-invasive method for modulating the activity of specific brain regions… Expand
    ConditionsFood-related Impulsivity, Impulsive Behavior
    InterventionDevice
    Interventional Clinical Trial
    This study will be the first to explore mindfulness as a prevention intervention among transition age youth and those with previous involvement in the juvenile or criminal justice… Expand
    ConditionsAlcohol Problem Drinking, Alcohol Use, Underage, Substance Use
    InterventionBehavioral
    Observational Clinical Trial
    drug addiction is a major health hazard that has its effect on personality and behavior including the impulsivity and pattern of decision making. It also has its effect on both the… Expand
    ConditionsAddiction
    InterventionDiagnostic Test
    Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.
    • 1,095
    • PDF
    Neuropsychological Approaches to Reasoning and Decision-Making
    • 54
    Orbitofrontal cortex and its contribution to decision-making.
    • J. Wallis
    • Psychology, Medicine
    • Annual review of neuroscience
    • 2007
    • 685
    • PDF
    Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
    • 497
    • PDF
    Impaired behavior on real-world tasks following damage to the ventromedial prefrontal cortex
    • 43
    Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions.
    • 1,709
    • PDF
    Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex.
    • 76
    • PDF
    Phineas gauged: decision-making and the human prefrontal cortex
    • 110
    Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans.
    • 594
    • PDF

    References

    SHOWING 1-10 OF 11 REFERENCES
    Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage
    • 438
    Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
    • 1,845
    Frontal lobes and the temporal organization of memory.
    • 478
    The Involvement of the Frontal Lobes in Cognitive Estimation
    • 667
    Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
    • 1,220
    Frontal Lobe Function and Dysfunction
    • 929
    • PDF
    Somatic markers and the guidance of behavior: Theory and preliminary testing.
    • 553
    Descartes’ Error. Emotion, Reason and the Human Brain. New York (Grosset/Putnam) 1994.
    • 2,684
    Descartes’ error: Emotion. rationality and the human brain
    • 1994
    The Prefrontal Cortex
    • 733