Insensitivity of the chicken embryo to the ototoxicity of aminoglycoside antibiotics and a loop diuretic.

Abstract

Guinea pigs are routinely used in the histological evaluation of the cochlea as a method of testing for ototoxicity, but the procedures are very time-consuming. Because the avian cochlea is easier to examine and newly hatched chicks are sensitive to the ototoxic effects of gentamicin, birds may be useful in testing for ototoxicity. The use of chicken… (More)

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