Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics.

@article{Hall1994InsensitivityOP,
  title={Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics.},
  author={Anita C Hall and William Robert Lieb and Nicholas P Franks},
  journal={Anesthesiology},
  year={1994},
  volume={81 1},
  pages={117-23}
}
BACKGROUND Voltage-gated Ca2+ channels long have been considered plausible targets for general anesthetics. Previous anesthetic studies have focused on L-, T-, or N-type channels, but there have been no studies on channels identified as P-type. Since P-type channels may be the most important voltage-gated Ca2+ channels involved in synaptic transmission in mammalian brain, it is important to establish their sensitivity to clinically relevant concentrations of general anesthetics. METHODS… CONTINUE READING