Insecticidal and neuroblocking potencies of variants of the imidazolidine moiety of imidacloprid-related neonicotinoids and the relationship to partition coefficient and charge density on the pharmacophore.

@article{Kagabu2007InsecticidalAN,
  title={Insecticidal and neuroblocking potencies of variants of the imidazolidine moiety of imidacloprid-related neonicotinoids and the relationship to partition coefficient and charge density on the pharmacophore.},
  author={Shinzo Kagabu and Rika Ishihara and Yosuke Hieda and Keiichiro Nishimura and Yuji Naruse},
  journal={Journal of agricultural and food chemistry},
  year={2007},
  volume={55 3},
  pages={812-8}
}
The pharmacophore of the neonicotinoid insecticide imidacloprid, nitroiminoimidazolidine, was modified to heterocycles such as thiazolidine, pyrrolidine, dihydroimidazole, dihydrothiazole, and pyridone conjugated to nitroimine (=NNO2) or nitromethylene (=CHNO2). Their 6-chloro-3-pyridylmethyl or 5-chloro-3-thiazolylmethyl derivatives were examined for… CONTINUE READING