Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti

  title={Insecticidal activity of isobutylamides derived from Piper nigrum against adult of two mosquito species, Culex pipiens pallens and Aedes aegypti},
  author={Il-Kwon Park},
  journal={Natural Product Research},
  pages={2129 - 2131}
  • I. Park
  • Published 20 October 2011
  • Chemistry, Medicine
  • Natural Product Research
The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD50 values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4 µg/♀) followed by guineensine (1.9 µg/♀), retrofractamide A (2.4 µg/♀) and pipercide (3.2 µg/♀). LD50 value of chlorpyrifos was 0.03 µg… 
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  • 1984
Mosquitoes and other biting Diptera
  • Vector Control (pp. 5–177)
  • 1997
Mosquitoes and other biting Diptera. Vector Control
  • 1997