Allergy to insect venom is IgE mediated. Untreated, it occasionally terminates fatally and often causes temporary illness. Medical intervention with venom immunotherapy in patients with prior systemic reactions presents reactions to stings by inducing IgG-antibody formation, although in some groups of patients this results in little real benefit. Emergency self-treatment kits (Epi-Pen and Epi-Pen Jr., Center Laboratories, Port Washington, N.Y.; Ana Kit, Hollister-Stier, Spokane, Wash.), if promptly and intelligently used, may reverse most moderate sting reactions. Some severe reactions require aggressive therapy. Until better treatment criteria are available, the most certain way of reducing the risk of systemic reactions to stings is with venom immunotherapy.