Insect nicotinic acetylcholine receptors (nAChRs): important amino acid residues contributing to neonicotinoid insecticides selectivity and resistance.

@inproceedings{Liu2008InsectNA,
  title={Insect nicotinic acetylcholine receptors (nAChRs): important amino acid residues contributing to neonicotinoid insecticides selectivity and resistance.},
  author={Zewen Liu and Xiangmei Yao and Yixi Zhang},
  year={2008}
}
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels which mediate fast cholinergic synaptic transmission in insect and vertebrate nervous systems. The great abundance of nAChRs within the insect central nervous system has led to the development of insecticides targeting these receptors, such as neonicotinoid insecticides. Neonicotinoid insecticides act selectively on insect nAChRs, accounting at least in part for the selective toxicity to insects over vertebrates. Some… CONTINUE READING

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