Insect Olfactory Receptor Complex Functions as a Ligand‐gated Ionotropic Channel

@article{Touhara2009InsectOR,
  title={Insect Olfactory Receptor Complex Functions as a Ligand‐gated Ionotropic Channel},
  author={Kazushige Touhara},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1170}
}
  • K. Touhara
  • Published 1 July 2009
  • Biology
  • Annals of the New York Academy of Sciences
In general, each insect olfactory sensory neuron expresses one member of the olfactory receptor (OR) gene family along with the highly conserved Or83b co‐receptor, and the two ORs form a heteromeric complex to function as a chemosensor. Here we provide evidence that heteromeric insect ORs comprise a novel class of ligand‐activated nonselective cation channels. Heterologous cells expressing silk moth, fruit fly, or mosquito heteromeric OR complexes exhibited extracellular calcium influx and… 
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TLDR
Evidence is provided that heteromeric insect ORs comprise a new class of ligand-activated non-selective cation channels and the fast response kinetics and OR-subunit-dependent K+ ion selectivity of the insect OR complex support the hypothesis that the complex between OR and Or83b itself confers channel activity.
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    Proceedings of the National Academy of Sciences of the United States of America
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TLDR
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