Insect Immunity Shows Specificity in Protection upon Secondary Pathogen Exposure

@article{Sadd2006InsectIS,
  title={Insect Immunity Shows Specificity in Protection upon Secondary Pathogen Exposure},
  author={Ben M. Sadd and Paul Schmid-Hempel},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={1206-1210}
}

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References

SHOWING 1-10 OF 29 REFERENCES

Adaptive innate immunity? Responsive-mode prophylaxis in the mealworm beetle, Tenebrio molitor

  • Y. MoretM. Siva-jothy
  • Biology
    Proceedings of the Royal Society of London. Series B: Biological Sciences
  • 2003
TLDR
It was found that pre–challenged larvae produced a long–lasting antimicrobial response, which provided a survival benefit when the larvae were exposed to fungal infection, suggesting that the observed response is functionally ‘adaptive’.

A diphasic immune response against bacteria in the American cockroach.

TLDR
It is found that the roach generates a diphasic response when injected with bacteria, displaying an acute non-specific phase initially, which is then superseded by a second response that is relatively long term and specific.

Ecological and evolutionary implications of immunological priming in invertebrates.

Specific memory within innate immune systems.

  • J. Kurtz
  • Biology, Psychology
    Trends in immunology
  • 2005

The immune response of Drosophila

TLDR
Analysis of this defence by molecular genetics has now provided a global picture of the mechanisms by which this insect senses infection, discriminates between various classes of microorganisms and induces the production of effector molecules, among which antimicrobial peptides are prominent.

Protection of Penaeus monodon against White Spot Syndrome Virus by Oral Vaccination

TLDR
Contrary to current assumptions that invertebrates do not have a true adaptive immune system, a specific immune response and protection can be induced in P. monodon, and these experiments open up new ways to benefit the WSSV-hampered shrimp farming industry.

Invertebrates versus Vertebrates Innate Immunity: In the Light of Evolution (‘Nothing in biology makes sense except in the light of evolution’ T. Dobzhansky, Amer Biol Teacher 1973;35:125–9)

  • Rinkevich
  • Biology
    Scandinavian journal of immunology
  • 1999
TLDR
An alternative idea suggesting that preserving the individuality against the threat of invading conspecific cells might have been the original function of the immune system is suggested, providing evidence for the crucial role of the vertebrate's innate immunity in signalling and triggering the acquired effector mechanisms.