Inscuteable and Staufen Mediate Asymmetric Localization and Segregation of prosperoRNA during Drosophila Neuroblast Cell Divisions

@article{Li1997InscuteableAS,
  title={Inscuteable and Staufen Mediate Asymmetric Localization and Segregation of prosperoRNA during Drosophila Neuroblast Cell Divisions},
  author={Peng Li and Xiaohang Yang and Martin Wasser and Yu Dong Cai and William N. Chia},
  journal={Cell},
  year={1997},
  volume={90},
  pages={437-447}
}
When neuroblasts divide, inscuteable acts to coordinate protein localization and mitotic spindle orientation, ensuring that asymmetrically localized determinants like Prospero partition into one progeny. staufen encodes a dsRNA-binding protein implicated in mRNA transport in oocytes. We demonstrate that prospero RNA is also asymmetrically localized and partitioned during neuroblast cell divisions, a process requiring both inscuteable and staufen. Inscuteable and Staufen interact and colocalize… CONTINUE READING
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