Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.

@article{Culurgioni2011InscuteableAN,
  title={Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions.},
  author={Simone Culurgioni and Andrea Alfieri and Valentina Pendolino and Federica Laddomada and Marina Mapelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 52},
  pages={20998-1003}
}
Coupling of spindle orientation to cellular polarity is a prerequisite for epithelial asymmetric cell divisions. The current view posits that the adaptor Inscuteable (Insc) bridges between Par3 and the spindle tethering machinery assembled on NuMALGNGαi(GDP), thus triggering apico-basal spindle orientation. The crystal structure of the Drosophila ortholog of LGN (known as Pins) in complex with Insc reveals a modular interface contributed by evolutionary conserved residues. The structure also… CONTINUE READING

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