Input-specific control of reward and aversion in the ventral tegmental area

  title={Input-specific control of reward and aversion in the ventral tegmental area},
  author={Stephan Lammel and Byung Kook Lim and Chen Ran and Kee Wui Huang and Michael J. Betley and Kay M. Tye and Karl Deisseroth and Robert C Malenka},
Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and whether inputs to the VTA differentially modulate such circuits. Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum… CONTINUE READING
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