Inotropic effects of diadenosine tetraphosphate (AP4A) in human and animal cardiac preparations.

  title={Inotropic effects of diadenosine tetraphosphate (AP4A) in human and animal cardiac preparations.},
  author={Ute Vahlensieck and Peter Bokn{\'i}k and Iva Gombosov{\'a} and Sabine Huke and Joerg Knapp and Bettina Linck and Hartmut L{\"u}ss and Frank Ulrich M{\"u}ller and Joachim Neumann and Mario C Deng and Hans Heinrich Scheld and H Jankowski and Hartmut Schl{\"u}ter and Walter Zidek and Norbert Zimmermann and W. Schmitz},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={288 2},
Diadenosine tetraphosphate (AP4A) is an endogenous compound and exerts diverse physiological effects in animal systems. However, the effects of AP4A on inotropy in ventricular cardiac preparations have not yet been studied. The effects of AP4A on force of contraction (FOC) were studied in isolated electrically driven guinea pig and human cardiac preparations. Furthermore, the effects of AP4A on L-type calcium current and [Ca]i were studied in isolated guinea pig ventricular myocytes. In guinea… CONTINUE READING
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